Custom Peptides
Cayman Chemical 2-ChloroadenosIn 10mg
A metabolically stable adenosine analog that binds to adenosine A1, A2A, and A3 receptors with Ki values of 300, 80, and 1,900 nM, respectively; anticonvulsive activity in a rat model of generalized seizures
Cayman Chemical Valerolactone 10mg
An analytical reference standard categorized as a prodrug form of γ-hydroxyvaleric acid; intended for research and forensic applications
Cayman Chemical GNTIhydrochlorIde 10mg
A κ-opioid receptor antagonist (Ki = 0.18 nM); selective for κ-opioid receptors over µ- and δ-opioid receptors in radioligand binding assays (Kis = 36.9 and 70 nM, respectively); inhibits agonist-induced [35S]GTPγS binding in CHO cells expressing human κ-opioid receptors (pA2 = 10.4); induces scratching behavior in mice at 0.3 mg/kg
Cayman Chemical SulfaethoxypyrIdazIn 10mg
A sulfonamide antibiotic; active against several strains of E. coli isolated from necropsied animals or poultry at 0.25 or 1 mg/ml; induces the formation of cataracts in dogs when administered at 150 mg/kg for 13-27 weeks
Cayman Chemical 2-ThIocytIdIn 10mg
A modified nucleobase; an intermediate in the synthesis of pyrimidine β-ribonucleosides and β-ribonucleotides
Cayman Chemical 28Deoxybetuln mthylenamIn 10mg
A derivative of betulin; has been used in the synthesis of triterpene derivatives with antiviral activity
Cayman Chemical Percazn 10mg
A typical antipsychotic; binds to the dopamine D1 receptor and androgen receptor (Kis = 0.01 and 3 µM, respectively); an α1-AR antagonist (IC50 = 4.1 nM in rat forebrain homogenates); an α2-AR antagonist (IC50 = 2 µM in rat cortical homogenates); inhibits SARS-CoV-2 Mpro activity by 55% at 100 µM; increases the number of entries into, and the percentage of time spent in, the open arms of the elevated plus maze in rats at 0.075 mg/kg
Cayman Chemical Vaborbactam 10mg
A β-lactamase inhibitor (Kis = 29-110 nM for class A and class C enzymes); selective for bacterial β-lactamases over a panel of mammalian serine proteases (IC50s = ≥1,000 μM); potentiates the activity of biapenem against K. pneumonia expressing KPC-2 at 0.02 μg/ml; potentiates the activity of carbapenem antibiotics against clinical isolates of various bacteria (MICs = ≤0.06-4 and 4-64 μg/ml in the presence and absence of compound, respectively); reduces the number of CFUs in the lung in a neutropenic mouse lung infection model when used in combination with biapenem or meropenem at 50 mg/kg
Cayman Chemical QuInacrIn nalog 34 10mg
An autophagy inhibitor (MEC = 0.5 µM in U2OS cells); induces lysosomal deacidification and accumulation of LC3-II in U2OS cells at 0.5 or 3 µM
Cayman Chemical Enarodustat 10MG
A pan HIF-PH inhibitor (Kis = 16, 61, and 101 nM for HIF-PH1, -2, and -3, respectively); increases EPO levels in Hep3B cells (EC50 = 4.7 µM); increases plasma EPO levels in control rats, as well as plasma EPO and hemoglobin levels in 5/6-nephrectomized rats at 3 mg/kg; decreases renal fatty acid and amino acid metabolism and increases renal glucose metabolism in streptozotocin-induced rat and alloxan-induced mouse models of diabetic nephropathy
Cayman Chemical 3hydroy PalmITC ACD mthy 10mg
An esterized FA involved in quorum sensing; increases levels of PhcA-regulated virulence factors, greater than 20-, 30-, and 25-fold for EPS I, EGL, and PME, respectively, at a concentration of 175 nM
Cayman Chemical 5methoxy TryptamInhydroch 10mg
An analytical reference standard categorized as a tryptamine; intended for research and forensic applications
Cayman Chemical TDFAtrIfluoroacetate salt 10mg
An inhibitor of JNK (IC50 280 nM) competitive for JNK1 binding with pepJIP1 (IC50 500 nM) selective for JNK over p38a mTOR and PI3Ka inhibits c-Jun phosphorylation induced by TNF-a (EC50 12 4 UM) restores insulin sensitivity in a mouse model of type 2 diabetes when administered at 25 mg/kg 30 minutes prior to insulin reduces human prostate strip contractions induced by phenylephrine or norepinephrine when applied at 30 UM and reduces phosphorylation of c-Jun a JNK substrate
Cayman Chemical ZnubrutInIb 10mg
A potent and covalent BTK inhibitor (IC50 = 0.3 nM); selective for BTK over a panel of 304 kinases at 1 μM; inhibits EGFR, Tec, Blk, BMX, HER4, and TXK (IC50s = 0.62-33 nM); inhibits phosphorylation of BTK at Y233 (IC50 = 1.8 nM) in Ramos cells; reduces viability of REC-1 cells (IC50 = 0.36 nM); reduces tumor volume in an OCI-LY10 DLBCL mouse xenograft model at 2.5 and 7.5 mg/kg